This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the effects of radiation therapy for preventing instrumentation track metastases in malignant pleural mesothelioma.

Secondary objectives include to determine:

• the true incidence of instrumentation track metastases in contemporary MPM patient populations;

• the impact of patient characteristics (e.g. histological subtype of MPM) and intervention characteristics (e.g. maximally invasive versus minimally invasive) on the risk of developing instrumentation track metastases;

• the impact of radiation treatment on secondary patient outcomes such as quality of life, survival time, and disease‐free interval; and

• the incidence of irradiation‐induced dermatitis in MPM patients receiving prophylactic radiotherapy.