This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the efficacy and safety of the use of anti‐angiogenic agents (VEGF inhibitors) in the adjuvant setting after resection in patients diagnosed with resectable colorectal cancer.
This would permit a summary of the safety and effectiveness of anti‐VEGF therapies overall, as well as in pre‐planned prognostic subgroups, and identify areas where further research could be directed.