This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

Diagnosis of acute pancreatitis in people with acute epigastric or diffuse abdominal pain

To compare the diagnostic accuracy of serum amylase, serum lipase, urinary trypsinogen‐2, and urinary amylase, either alone or in combination, in the diagnosis of acute pancreatitis in patients with acute onset of a persistent, severe, epigastric pain or diffuse abdominal pain.

Diagnosis of necrotising pancreatitis in people with established diagnosis of acute pancreatitis

To compare the diagnostic accuracy of CRP, procalcitonin, or LDH, either alone or in combination, in the diagnosis of necrotising pancreatitis in patients with acute pancreatitis and without organ failure.