This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

Our objectives are to determine:

• the benefits and harms (both absolute and relative) of all topical and systemic interventions for the treatment of uraemic itch, either alone or in combination, when compared with placebo or standard care; and

• if the effects of these interventions vary depending on co‐interventions, dose strength or frequency, stage of kidney disease or method of dialysis used (where applicable).