Cochrane Database of Systematic Reviews Protocol - Intervention
Oral polio vaccine plus inactivated polio vaccine versus oral polio vaccine alone for reducing polio in children under two years of age
Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
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To determine the effects of combined immunisation with OPV and IPV on intestinal mucosal immunity
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To determine any variation in effect with type of vaccine, number of doses, age at first dose, by human immunodeficiency virus (HIV) status or in high and low income countries
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To determine any serious adverse outcomes
