This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

Primary objective

To determine which treatment regimen (that must include one or more of chemotherapy, radiotherapy or biotherapy) given with the intention to cure HPV‐positive local advanced oropharyngeal squamous cell cancer will lead to the best outcomes in terms of overall survival, treatment‐related morbidity and side effects. Comparison will be drawn between treatment regimens that have different therapeutic agents, dosing or delivery methods.

Secondary objective

To determine the implications of treatment modalities in terms of quality of life, disease‐free survival and costs.