This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

1. To perform a systematic review of Internet‐based HIV prevention intervention studies in MSM compared with standard or other interventions or no interventions. All randomized clinical trials and rigorously designed quasi‐experimental studies will be included. The following key elements of the Internet‐based HIV interventions will be examined

• Intervention strategies applied in the studies

• Theoretical bases for these interventions

• Measurements of intervention outcomes

• Barriers and challenges in intervention delivery, informed consent provision, participation incentive distribution, data collection and subject retention, etc.

• Cultural and geographical differences in the interventions

2. To perform a meta‐analysis, when possible and appropriate, of the efficacy of Internet‐based HIV interventions among MSM.