This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the effects (benefits and harms) of platelet‐rich therapies for treating long bone fractures, non‐unions and defects in adults.

We plan to compare platelet‐rich therapy versus placebo or no platelet‐rich therapy, usually in addition to standard‐of‐care treatment strategies, in adults with the following conditions:

• acute complete long bone fracture, long bone stress fracture, osteotomy

• non‐united (delayed union and non‐union) long bone fracture

• long bone defect (critical size defect)