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Cochrane Database of Systematic Reviews Protocol - Intervention

Hypomethylating agents for adult patients with acute myeloid leukaemia

This is not the most recent version

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The main objective of this systematic review is to evaluate the role of hypomethylating agents (i.e. 5‐Aza, DAC) for untreated and previously treated patients with AML. For this purpose we will critically, systematically, and statistically analyse the efficacy of hypomethylating agents compared to best supportive care/no treatment as well as to other agents/chemotherapy regimens with regard to overall survival (OS), treatment‐related mortality (TRM), complete response rate (CR), progression‐free survival, quality of life, and adverse events.