EEG for children with complex febrile seizures
Abstract
Background
This is an updated version of original Cochrane review published in Issue 1, 2014.
Febrile seizures can be classified as simple or complex. Complex febrile seizures are associated with fever that lasts longer than 15 minutes, occur more than once within 24 hours and are confined to one side of the child's body. It is common in some countries for doctors to recommend an electroencephalograph (EEG) for children with complex febrile seizures. A limited evidence base is available to support the use of EEG and its timing after complex febrile seizures among children.
Objectives
To assess the use of EEG and its timing after complex febrile seizures in children younger than five years of age.
Search methods
For the latest update of this review, we searched the Cochrane Epilepsy Group Specialized Register (6 July 2015), the Cochrane Central Register of Controlled Trials (CENTRAL, 2005, Issue 6), MEDLINE (6 July 2015) and ClinicalTrials.gov (6 July 2015). We applied no language restrictions.
Selection criteria
All randomised controlled trials (RCTs) that examined the utility of an EEG and its timing after complex febrile seizures in children.
Data collection and analysis
Review authors selected and retrieved the articles and independently assessed which articles should be included. We resolved disagreements by discussion and by consultation with the Cochrane Epilepsy Group. We applied standard methodological procedures expected by Cochrane.
Main results
Of 37 potentially eligible studies, no RCTs met the inclusion criteria.
Authors' conclusions
We found no RCTs as evidence to support or refute the use of EEG and its timing after complex febrile seizures among children. An RCT can be planned in such a way that participants are randomly assigned to the EEG group and to the non‐EEG group with sufficient sample size. Since the last version of this review, we found no new studies.
PICOs
Plain language summary
EEG for children with complex febrile seizures
Background
Febrile seizures (fits) can be classified as simple or complex. Complex febrile seizures are associated with a high temperature (fever), last longer than 15 minutes, occur more than once within 24 hours and are confined to one side of the child's body. It is common in some countries for doctors to recommend an electroencephalograph (EEG), which records electrical activity in the brain, on children with complex febrile seizures. The EEG may help identify why the seizures occur and predict the risk of future seizures.
Study characteristics
We searched scientific databases for randomised controlled trials (clinical studies where people are randomly put into one of two or more treatment groups; these are regarded as a gold standard for trial design) that compared EEG with no EEG or a delayed EEG (occurring at second seizure) in children under five years of age with a first complex febrile seizure. We planned to look at the number of seizures that occurred at one, two, 12 and 24 months after EEG.
Key results and quality of the evidence
We attempted to search all possible sources but were unable to find any randomised controlled trials to address the issue up to 6 July 2015. We concluded that there is no high‐quality evidence to support or refute the use of an EEG and its timing after complex febrile seizures in children. Therefore, well‐designed randomised controlled trials are required. We intend to update this review regularly with the hope that new randomised studies will be reported in the future.
