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Cochrane Database of Systematic Reviews Protocol - Intervention

Prophylactic antibiotics to reduce morbidity and mortality in newborn infants with intercostal catheters

This is not the most recent version

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The objective of this review is to determine the effect of prophylactic antibiotics compared to selective use of antibiotics on mortality and morbidity (especially septicaemia) in neonates undergoing placement of an intercostal catheter.

Data permitting, subgroup analysis will be done to determine whether results differ by:

  1. term (> 37 weeks gestation) versus preterm (< 37 weeks gestation);

  2. type of antibiotic (e.g., penicillins, macrolides, aminoglycosides, cephalosporins, or combinations);

  3. type of indication for catheter (e.g., pneumothorax, pleural effusion, post‐operative indications);

  4. type of prophylaxis (e.g., single dose/s with insertion, ongoing prophylaxis for the life of the catheter);

  5. whether infant was on antibiotics at the time of study entry.