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Cochrane Database of Systematic Reviews Protocol - Intervention

Surfactant for bacterial pneumonia in term and late preterm infants

This is not the most recent version

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To evaluate the effect of exogenous surfactant administration on death and respiratory morbidity in term and near term infants with bacterial pneumonia.

Bacterial pneumonia will be defined as either proven bacterial pneumonia or clinical pneumonia; 1) proven pneumonia will be defined as meeting clinical, radiological and identification of the bacteria through isolation or antibody identification, 2) clinical pneumonia will involve the assessment by the treating clinician that the infant has a pulmonary infection that has been treated with a complete course of antibiotics (the type and length of antibiotic course, as specified by the study) but where the cultures have not isolated any micro‐organisms.

Subgroup analyses will be performed if possible based on the following:

1) Diagnosis of pneumonia: proven vs. clinical;

2) Period of infection: primary intrauterine infection, early (≤ 48 hours) and late onset (> 48 hours) infection;

3) Type of infection: nosocomial and community acquired infections; ventilator‐associated and nonventilator‐associated pneumonia; Group B streptococcal, gram negative and Chlamydia pneumonia;

4) Type of surfactant given: animal derived, synthetic and protein containing synthetic surfactant;

5) Dosing of surfactant: single and multiple doses;

6) Administration of surfactant: bolus administration, lavage or nebulised;

7) Concurrent administration of immunoglobulin.