This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To determine the benefits and harms of the interventions used for treating osteochondral defects of the talus in adults. This will include comparisons of interventions in the following categories:

• Any intervention versus no intervention or placebo control;

• Different methods of non‐surgical treatment;

• Surgical versus non‐surgical treatment;

• Different methods of surgical treatment.