Cochrane Database of Systematic Reviews Protocol - Diagnostic
Triage with human papillomavirus (HPV) testing versus repeat cytology for underlying high‐grade cervical intra‐epithelial neoplasia in women with minor cytological lesions
Abstract
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:
In this meta‐analysis, the authors aim to give an answer to the following questions.
Primary objectives
For studies where both triage methods were assessed, what is the:
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accuracy of hrHPV testing with HC2 to find underlying CIN2+ or CIN3+?
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accuracy of repeat cytology to find underlying CIN2+ or CIN3+? Three different cut‐offs to define a positive repeat cytology will be considered: ASCUS or worse (ASCUS+), LSIL or worse (LSIL+), and high‐grade squamous intraepithelial lesions or more (HSIL+);
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relative sensitivity and relative specificity of HC2 triage compared to repeat cytology?
