This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To evaluate the efficacy of different regimens of PPIs in the management of acute bleeding from peptic ulcer using evidence from direct comparison RCTs. We specifically intend to assess the differential effect of the dose and route of administration of PPI on mortality, rebleeding, surgical intervention, further EHT, length of hospital stay, transfusion requirements and adverse events.