This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

Primary Objective:

To assess the effects of interventions for treating neonatal hyperglycemia in the very low birth weight neonate receiving total or partial parenteral nutrition. Specific interventions to be reviewed are:

(i) restriction in the rate of parenteral glucose infusion, with or without any increase in the provision of parenteral lipids or amino acids (compared with no restriction in the rate of parenteral glucose infusion)

(ii) insulin infusion (compared with no restriction in the rate of parenteral glucose infusion)

(iii) insulin infusion (compared with restriction in the rate of parenteral glucose infusion)

Secondary Objectives:

Data permitting, sub‐group analyses will be carried out according to population:

(a) Birth weight 500 ‐ 749 g; 750 ‐ 999 g; 1000 ‐ 1499 g

(b) Criterion for hyperglycemia at study entry: 8.3 ‐ 13.8 mM/L (150 ‐ 250 mg/dL); > 13.8 mM/L (> 250 mg/dL)

(c) Associated morbidity at study entry: high/low morbidity score or as reported by author