This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

Primary:

• To assess the efficacy of posatirelin treatment in improving function, cognition, mood, behaviour, quality of life, and mortality in older persons with dementia.

Secondary:

• To assess the efficacy of posatirelin treatment in decreasing medication use for the purpose of minimizing negative drug interactions (for example, ChEIs, whose effectiveness can decrease when paired with incontinence medication) and number of adverse drug reactions.

• To make recommendations for consumers, healthcare professionals, decision‐makers, and researchers regarding the efficacy of posatirelin treatment for dementia.