This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The primary objective of this review is to systematically evaluate the efficacy of type I IFN therapy (including IFN‐β‐1a, IFN‐β‐1b, IFN‐α‐2a, IFN‐α‐2b and associated pegylated formulations) in inducing remission in ulcerative colitis. The secondary objectives are to determine improvement in disease activity aside from inducing remission (including quality of life) and to evaluate adverse events associated with IFN therapy for the treatment of UC.