This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The primary aim of this review is to identify and summarize the available data from randomized controlled trials comparing the use of propofol to traditional agents for sedation during colonoscopy in terms of its relative effectiveness, acceptance and safety. Our secondary goal is to identify and summarize the data from randomized controlled trials comparing the administration of propofol by anesthesiologists to non‐anesthesiologists for sedation during colonoscopy.