This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the benefits and risks of primary peritoneal drainage compared to laparotomy as the initial treatment for perforated necrotizing enterocolitis in preterm and LBW infants.

Sub‐group analysis will be planned for the following pre‐specified sub‐categories:
Gestational age (< 30 wks); birthweight (< 1000g).