This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To determine the efficacy of antidotes for the treatment of acute cardenolide poisoning, in particular atropine, isoprenaline (isoproterenol), multiple‐dose activated charcoal, frustose‐1,6‐diphosphate, sodium bicarbonate, magnesium, phenytoin and anti‐digoxin Fab antitoxin.