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Cochrane Database of Systematic Reviews Protocol - Intervention

Anti‐angiogenic therapy for metastatic colorectal cancer

This is not the most recent version

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To evaluate, in terms of efficacy and toxicity, the effect of anti‐angiogenic therapy ‐ either alone or in combination with other targeted drugs ‐ in addition to chemotherapy in patients with metastatic CRC.

Comparisons will be as follows:

  • 1) First‐line chemotherapy in combination with angiogenesis inhibitor, to chemotherapy without angiogenesis inhibitor

  • 2) Second‐line chemotherapy in combination with angiogenesis inhibitor, to chemotherapy without angiogenesis inhibitor

A large number of compounds with various mechanisms of action are currently under development. Therefore, updates of this review will consider the mechanism of action, whether the drug is an antibody or a small molecule, and a direct, indirect or mixed inhibitor for classification, as well as different types of chemotherapy, schedules of anti‐angiogenic agents, and combinations of different anti‐angiogenic strategies.
Studies using anti‐angiogenic therapies as second line will be classified according their prior use in first line as well. This classification will be adopted depending on the availability of relevant studies in the future. As soon as studies using combinations of anti‐angiogenic and other targeted drugs become available, further comparisons will be added.