This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To assess the efficacy of antiviral agents as adjuvant therapy in the management of recurrent respiratory papillomatosis (RRP) in children and adults.

Therapeutic agents with antiviral properties but which are not themselves antiviral agents (e.g. Alpha‐interferon, vaccination, Indole‐3‐carbinol) will not be included in this review.