This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

This review consists of two comparisons, which are to be analysed separately:

(I) To determine whether high‐dose chemotherapy and autologous stem cell transplantation is more effective than conventional chemotherapy for patients with multiple myeloma,
and
(II) to determine whether tandem high‐dose chemotherapy and autologous stem cell transplantation is more effective than single high‐dose chemotherapy and autologous stem cell transplantation for patients with multiple myeloma.