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Cochrane Database of Systematic Reviews Protocol - Intervention

Positive end‐expiratory pressure for infants requiring conventional mechanical ventilation for hyaline membrane disease or bronchopulmonary dysplasia

This is not the most recent version

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

1) In newborn infants requiring conventional mechanical ventilation for hyaline membrane disease, does applying high PEEP reduce mortality and morbidity, as measured by neurodevelopmental outcome, compared to low PEEP?
2) In infants with bronchopulmonary dysplasia requiring conventional mechanical ventilation, does high PEEP decrease mortality and morbidity, as measured by neurodevelopmental outcome, compared to low PEEP?
3) In newborn infants with hyaline membrane disease, which method of determining the level of PEEP leads to a decreased mortality, and morbidity as measured by neurodevelopmental outcome?

We will use the following definitions:

  • PEEP (Any level of PEEP)

  • ZEEP (Zero PEEP)

  • Low PEEP (PEEP < 5cm H2O)

  • High PEEP (PEEP ³ 5 cm H2O)

Subgroup analyses will be performed to determine the effects of high PEEP and low PEEP in hyaline membrane disease in the following subgroups:

  • preterm infants < 28 weeks gestational age

  • preterm infants 28 ‐31 weeks gestational age

  • preterm infants ≥ 32 weeks gestational age

  • prior to surfactant therapy

  • post‐surfactant therapy