This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To determine the effectiveness of antibiotics in the treatment of chronic osteomyelitis.
We will examine the following hypotheses:
1. Different antibiotic treatment regimes in terms of duration and methods of administration may have different effectiveness in chronic osteomyelitis.
2. Patients with infection caused by different bacteria may have different rates of sustained remission after antibiotic therapy.