This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

This Cochrane review will focus on the treatment of the peripheral neurological features in mitochondrial disorders, which we will group together as "mitochondrial myopathies". Mitochondrial encephalopathy will be considered in another review.

It is important to note that some individuals with mitochondrial myopathy also have central neurological features that could interfere with the assessment of the myopathy (such as dementia or spasticity). For this review we will only include evidence where the muscle involvement can be assessed objectively.

The objective of this review is to examine the efficacy of pharmacological treatments, and non‐pharmacological treatments (vitamins and food supplements), and physical training in improving the symptoms, signs, disability and quality of life in individuals with mitochondrial myopathy.