Scolaris Content Display Scolaris Content Display

Treatment for avascular necrosis of bone in people with sickle cell disease

This is not the most recent version

Abstract

Background

Avascular necrosis of bone is a frequent and severe complication of sickle cell disease and its treatment is not standardised. It is therefore important to gather evidence about the safety and effectiveness of different interventions.

Objectives

To determine the impact of surgery compared to non‐surgical management on both the short‐ and the long‐term outcomes (efficacy, safety, and adverse events) for people with sickle cell disease‐related avascular necrosis.

Search methods

We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register, which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. Additional randomized controlled trials were sought from the reference lists of the trials found and reviews identified by the search strategy.

Date of the most recent search: June 2006.

Selection criteria

All randomized or quasi‐randomized controlled trials (published or unpublished).

Data collection and analysis

One ongoing clinical trial has been identified but no data are available as yet for inclusion in the review.

Main results

Five trials were identified by the searches. Four trials were not eligible for inclusion and one is an ongoing clinical trial.

Authors' conclusions

We were unable to find any evidence from completed randomized controlled trials assessing treatments for avascular necrosis in people with sickle cell disease. We await the results of an ongoing clinical trial to assess the benefits and risks of a surgical approach compared to a non‐surgical approach for improving survival and quality of life for people with sickle cell disease‐related avascular necrosis of bone.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Plain language summary

No randomized controlled trials have been identified which assess the effectiveness of treatments for avascular necrosis of bone in people with sickle cell disease

There is currently insufficient evidence, in the form of randomised controlled trials, to assess the beneficial and harmful effects of specific therapies for avascular necrosis of bone in people with sickle cell disease. High quality randomised controlled trials are required to assess these treatments.