Appendix 1. MEDLINE search strategy

Database: Ovid MEDLINE(R) 1946 to Present with Daily Update
‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐
1 exp angiotensin receptor antagonists/
2 (angiotensin adj3 (receptor antagon$ or receptor block$)).tw.
3 (arb or arbs).tw.
4 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or forasartan or irbesartan or KT3‐671 or losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan).tw.
5 or/1‐4
6 blood pressure monitoring, ambulatory/
7 ((blood pressure or bp or dbp or sbp) adj10 (ambulatory or monitor$)).tw.
8 ((24 hour? or 24h or 24hr or 24 hr or 24‐h or hourly) adj10 (ambulatory or blood pressure or bp or dbp or monitor$ or sbp)).tw.
9 (abp or abpm).tw.
10 *time factors/
11 time course?.tw.
12 circadian.mp.
13 or/6‐12
14 hypertension/
15 (antihypertens$ or hypertens$).tw.
16 exp blood pressure/
17 (blood pressure or bloodpressure).tw.
18 or/14‐17
19 randomized controlled trial.pt.
20 controlled clinical trial.pt.
21 randomized.ab.
22 placebo.ab.
23 drug therapy.fs.
24 randomly.ab.
25 trial.ab.
26 groups.ab.
27 or/19‐26
28 animals/ not (humans/ and animals/)
29 27 not 28
30 5 and 13 and 18 and 29
31 remove duplicates from 30