Scolaris Content Display Scolaris Content Display

Study flow diagram.
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Figure 1

Study flow diagram.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 1 Pain intensity at rest (0 ‐ 23 hours postoperatively).
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Analysis 1.1

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 1 Pain intensity at rest (0 ‐ 23 hours postoperatively).

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 2 Pain intensity at rest (24 ‐ 47 hours postoperatively).
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Analysis 1.2

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 2 Pain intensity at rest (24 ‐ 47 hours postoperatively).

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 3 Pain intensity at rest (48 ‐ 72 hours postoperatively).
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Analysis 1.3

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 3 Pain intensity at rest (48 ‐ 72 hours postoperatively).

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 4 Pain intensity on movement (0 ‐ 23 hours postoperatively).
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Analysis 1.4

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 4 Pain intensity on movement (0 ‐ 23 hours postoperatively).

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 5 Pain intensity on movement (24 ‐ 47 hours postoperatively).
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Analysis 1.5

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 5 Pain intensity on movement (24 ‐ 47 hours postoperatively).

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 6 Pain intensity on movement (48 ‐ 72 hours postoperatively).
Figures and Tables -
Analysis 1.6

Comparison 1 Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone, Outcome 6 Pain intensity on movement (48 ‐ 72 hours postoperatively).

Comparison 1. Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain intensity at rest (0 ‐ 23 hours postoperatively) Show forest plot

7

390

Mean Difference (IV, Random, 95% CI)

‐11.85 [‐20.45, ‐3.25]

1.1 Total knee arthroplasty

3

183

Mean Difference (IV, Random, 95% CI)

‐19.50 [‐35.01, ‐3.99]

1.2 Anterior cruciate ligament reconstruction

3

167

Mean Difference (IV, Random, 95% CI)

‐2.82 [‐8.03, 2.38]

1.3 Partial menisectomy arthroscopically

1

40

Mean Difference (IV, Random, 95% CI)

‐15.60 [‐22.84, ‐8.36]

2 Pain intensity at rest (24 ‐ 47 hours postoperatively) Show forest plot

6

320

Mean Difference (IV, Random, 95% CI)

‐12.92 [‐19.82, ‐6.02]

2.1 Total knee arthroplasty

4

224

Mean Difference (IV, Random, 95% CI)

‐15.05 [‐24.11, ‐5.98]

2.2 Anterior cruciate ligament reconstruction

1

56

Mean Difference (IV, Random, 95% CI)

‐0.10 [‐11.59, 11.39]

2.3 Partial menisectomy arthroscopically

1

40

Mean Difference (IV, Random, 95% CI)

‐15.50 [‐22.27, ‐8.73]

3 Pain intensity at rest (48 ‐ 72 hours postoperatively) Show forest plot

4

210

Mean Difference (IV, Random, 95% CI)

‐9.72 [‐16.75, ‐2.70]

3.1 Total knee arthroplasty

3

154

Mean Difference (IV, Random, 95% CI)

‐13.73 [‐18.21, ‐9.26]

3.2 Anterior cruciate ligament reconstruction

1

56

Mean Difference (IV, Random, 95% CI)

‐0.5 [‐10.60, 9.60]

4 Pain intensity on movement (0 ‐ 23 hours postoperatively) Show forest plot

5

304

Mean Difference (IV, Random, 95% CI)

‐6.95 [‐15.92, 2.01]

4.1 Total knee arthroplasty

2

153

Mean Difference (IV, Random, 95% CI)

‐12.93 [‐26.62, 0.75]

4.2 Anterior cruciate ligament reconstruction

2

111

Mean Difference (IV, Random, 95% CI)

0.10 [‐7.49, 7.70]

4.3 Partial menisectomy arthroscopically

1

40

Mean Difference (IV, Random, 95% CI)

‐7.5 [‐19.91, 4.91]

5 Pain intensity on movement (24 ‐ 47 hours postoperatively) Show forest plot

3

182

Mean Difference (IV, Random, 95% CI)

‐8.87 [‐27.77, 10.03]

6 Pain intensity on movement (48 ‐ 72 hours postoperatively) Show forest plot

2

112

Mean Difference (IV, Fixed, 95% CI)

‐6.19 [‐11.76, ‐0.62]

Figures and Tables -
Comparison 1. Peripheral nerve blocks adjunctive to systemic analgesia versus systemic analgesia alone