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Adapted QUOROM (quality of reporting of meta‐analyses) flow‐chart of study selection
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Figure 1

Adapted QUOROM (quality of reporting of meta‐analyses) flow‐chart of study selection

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Comparison 1 Adverse events, Outcome 1 Incidence of xerostomia (dry mouth and hypogeusia).
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Analysis 1.1

Comparison 1 Adverse events, Outcome 1 Incidence of xerostomia (dry mouth and hypogeusia).

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Comparison 1 Adverse events, Outcome 2 Reduction of blood pressure.
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Analysis 1.2

Comparison 1 Adverse events, Outcome 2 Reduction of blood pressure.

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Comparison 2 Decrease in uptake of technetium‐99m by parotid gland at 12 months, Outcome 1 Decrease in uptake of technetium‐99m by parotid gland at 12 m.
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Analysis 2.1

Comparison 2 Decrease in uptake of technetium‐99m by parotid gland at 12 months, Outcome 1 Decrease in uptake of technetium‐99m by parotid gland at 12 m.

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Comparison 2 Decrease in uptake of technetium‐99m by parotid gland at 12 months, Outcome 2 Decrease in uptake of technetium‐99m by mandibular gland at 12 m.
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Analysis 2.2

Comparison 2 Decrease in uptake of technetium‐99m by parotid gland at 12 months, Outcome 2 Decrease in uptake of technetium‐99m by mandibular gland at 12 m.

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Comparison 3 Radioactive iodine dose, Outcome 1 Decrease in uptake of technetium‐99m by parotid gland at 3 m.
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Analysis 3.1

Comparison 3 Radioactive iodine dose, Outcome 1 Decrease in uptake of technetium‐99m by parotid gland at 3 m.

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Comparison 3 Radioactive iodine dose, Outcome 2 Decrease in uptake of technetium‐99m by submandibular glands at 3 m.
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Analysis 3.2

Comparison 3 Radioactive iodine dose, Outcome 2 Decrease in uptake of technetium‐99m by submandibular glands at 3 m.

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Table 1. Study populations data

study ID

intervention

[n] screened

[n] randomised

[n] safety

[n] ITT

[n] finishing study

comments

Bohuslavizki 1998b

amifostine (I)

placebo (C)

I: 25

C: 25

Total: 50

I: 25

C: 25

Total: 50

I: 25

C: 25

Total: 50

I: not mentioned

C: not mentioned

I: 25

C: 25

Total: 50

none

Kim 2008

amifostine (I)

placebo (C)

I: 42

C: 38

Total: 80

I: 42

C: 38

Total: 80

I: 42

C: 38

Total: 80

I: not mentioned

C: not mentioned

I: 42

C: 38

Total: 80

none

ITT: intention‐to‐treat
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Table 1. Study populations data
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Comparison 1. Adverse events

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of xerostomia (dry mouth and hypogeusia) Show forest plot

2

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

2 Reduction of blood pressure Show forest plot

2

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only
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Comparison 1. Adverse events
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Comparison 2. Decrease in uptake of technetium‐99m by parotid gland at 12 months

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Decrease in uptake of technetium‐99m by parotid gland at 12 m Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2 Decrease in uptake of technetium‐99m by mandibular gland at 12 m Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
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Comparison 2. Decrease in uptake of technetium‐99m by parotid gland at 12 months
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Comparison 3. Radioactive iodine dose

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Decrease in uptake of technetium‐99m by parotid gland at 3 m Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2 Decrease in uptake of technetium‐99m by submandibular glands at 3 m Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
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Comparison 3. Radioactive iodine dose
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