1 Treatment failure at day 63 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Treatment failure at day 63 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Anaemia Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Tinnitus Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Mean birthweight Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7 Preterm delivery Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

8 Gestational age Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

9 Intra‐uterine growth retardation Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

10 Congenital abnormality Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at day 63 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Anaemia Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 On admission

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 Day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.3 Day 28

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.4 Day 42

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.5 Day 63

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Nervous system adverse events Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Abnormal neurology

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Blurring vision

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 Dizziness

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.4 Headache

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.5 Tinnitus

2

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.6 Vertigo

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Gastrointestinal adverse events Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4.1 Abdominal pain

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Anorexia

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.3 Nausea

2

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.4 Vomiting

2

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Other adverse events Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5.1 Hypoglycaemia

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5.2 Muscle and joint pain

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5.3 Palpitations

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7 Mean birthweight Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8 Abortion Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9 Neonatal jaundice Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at delivery or day 40 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Treatment failure at delivery or day 40 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Maternal anaemia Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Perinatal death Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Neonatal death Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at delivery or 40 days Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Treatment failure at delivery or day 40 (excludes new infections, detected by PCR) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Maternal anaemia Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Perinatal death Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Neonatal death Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Mean parasite clearance time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2 Mean gestational age at delivery Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1 Treatment failure at 48 hours (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Mean parasite clearance time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Anaemia at day 7 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Mean birthweight Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6 Mean gestational age at delivery Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1 Mean fever clearance time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2 Mean parasite clearance time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Adverse events Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Abdominal discomfort

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Dizziness

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Mean birthweight Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1 Treatment failure at day 28 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Treatment failure at day 28 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Adverse events Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Any "side effect" at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Any "side effect" at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 General weakness at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.4 General weakness at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.5 Dizziness at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.6 Dizziness at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.7 Vomiting day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.8 Vomiting at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.9 Itching at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.10 Itching at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.11 Nausea at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.12 Nausea at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Preterm delivery Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at day 28 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Treatment failure at day 28 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Adverse events Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Any "side effect" at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Any "side effect" at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 General weakness at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.4 General weakness at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.5 Dizziness at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.6 Dizziness at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.7 Vomiting at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.8 Vomiting at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.9 Itching at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.10 Itching at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.11 Nausea at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.12 Nausea at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Preterm delivery Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at delivery or day 40 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Treatment failure at delivery or day 40 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Maternal anaemia Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Perinatal death Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Neonatal death Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at day 14 Show forest plot

2

544

Risk Ratio (M‐H, Fixed, 95% CI)

0.56 [0.29, 1.09]

2 Treatment failure at day 28 Show forest plot

2

538

Risk Ratio (M‐H, Fixed, 95% CI)

0.46 [0.33, 0.64]

3 Treatment failure at day 28 (excludes new infections, detected by PCR) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Adverse events Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4.1 Any "side effect" at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Any "side effect" at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.3 General weakness at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.4 General weakness at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.5 Dizziness at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.6 Dizziness at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.7 Vomiting at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.8 Vomiting at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.9 Itching at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.10 Itching at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.11 Nausea at day 3

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.12 Nausea at day 7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Low birthweight Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Preterm delivery Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1 Treatment failure at day 14 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 3‐day clindamycin

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 5‐day clindamycin

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Adverse event: itching Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 3‐day clindamycin

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 5‐day clindamycin

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Adverse event: diarrhoea Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 3‐day clindamycin

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 5‐day clindamycin

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]