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Comparison 1 reduction in pain intensity, Outcome 1 Acute and chronic pain continuous data ‐ difference posttreatment minus baseline.
Figures and Tables -
Analysis 1.1

Comparison 1 reduction in pain intensity, Outcome 1 Acute and chronic pain continuous data ‐ difference posttreatment minus baseline.

Comparison 1 reduction in pain intensity, Outcome 2 Acute pain dichotomous data.
Figures and Tables -
Analysis 1.2

Comparison 1 reduction in pain intensity, Outcome 2 Acute pain dichotomous data.

Comparison 1 reduction in pain intensity, Outcome 3 Acute and chronic pain continous data ‐ mean after treatment.
Figures and Tables -
Analysis 1.3

Comparison 1 reduction in pain intensity, Outcome 3 Acute and chronic pain continous data ‐ mean after treatment.

Table 1. Side effects

Author/Year

Substance

Type of side effect

Percentage

Ginsberg 1983

Tiapride

Drowsiness (moderate to mild), mild gastric intolerance

38.1%

Lechin 1989

Pimozide

Physical and mental retardation, hand tremors, memory impairment, involuntary movements during sleep (jerkings) and slight Parkinson's disease manifestations

83.3%

Langemark 1994

Sulpiride

Sedation, depression, nausea, sleep disturbance, increased dreaming, uneasiness, weight gain, obstipation, amenorrhoe, galactorrhoe, impotence, restless legs, micturation difficulties, polyuria, accomodation difficulties, dry mouth, orthostatic hypotension

author only provided incidences, at least 34%

Roux 1983

Tiapride

no side effects reported

‐‐

Johnston 1972

Thioridazine

No untoward effects were observed or reported at any time during the study.

‐‐

Davidsen 1979

Levomepromazine

Dry mouth

59%

Graff‐Radford 2000

Fluphenazine

Sleepiness, dry mouth

‐‐

Zitman 1991

Flupentixol

Dry mouth

‐‐

Judkins 1982

Haloperidol

No serious side effects were observed, dry mouth

‐‐

Bussone 1980

Tiapride

No extrapyramidal, neuroendocrine or neurovegetative side effects were observed.

‐‐

Honkaniemi 2006

Haloperidol

Motor agitation, sedation, hyperventilation and shortness of breath

80%

Figures and Tables -
Table 1. Side effects
Comparison 1. reduction in pain intensity

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Acute and chronic pain continuous data ‐ difference posttreatment minus baseline Show forest plot

4

148

Mean Difference (IV, Fixed, 95% CI)

‐2.16 [‐1.00, ‐1.32]

1.1 acute

1

40

Mean Difference (IV, Fixed, 95% CI)

‐4.52 [‐5.88, ‐3.16]

1.2 chronic

3

108

Mean Difference (IV, Fixed, 95% CI)

‐0.71 [‐1.78, 0.35]

2 Acute pain dichotomous data Show forest plot

2

82

Risk Ratio (M‐H, Fixed, 95% CI)

0.43 [0.25, 0.73]

2.1 acute

2

82

Risk Ratio (M‐H, Fixed, 95% CI)

0.43 [0.25, 0.73]

3 Acute and chronic pain continous data ‐ mean after treatment Show forest plot

4

148

Mean Difference (IV, Fixed, 95% CI)

‐1.78 [‐2.71, ‐0.85]

3.1 acute

1

40

Mean Difference (IV, Fixed, 95% CI)

‐4.05 [‐5.61, ‐2.49]

3.2 chronic

3

108

Mean Difference (IV, Fixed, 95% CI)

‐0.53 [‐1.68, 0.63]

Figures and Tables -
Comparison 1. reduction in pain intensity