Scolaris Content Display Scolaris Content Display

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 1 Growth rates during trial period.
Figures and Tables -
Analysis 1.1

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 1 Growth rates during trial period.

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 2 Growth parameters at 6 months post ‐term.
Figures and Tables -
Analysis 1.2

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 2 Growth parameters at 6 months post ‐term.

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 3 Growth parameters at 9 months post ‐term.
Figures and Tables -
Analysis 1.3

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 3 Growth parameters at 9 months post ‐term.

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 4 Growth parameters at 12‐18 months post ‐term.
Figures and Tables -
Analysis 1.4

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 4 Growth parameters at 12‐18 months post ‐term.

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 5 Development.
Figures and Tables -
Analysis 1.5

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 5 Development.

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 6 Bone mineralisation.
Figures and Tables -
Analysis 1.6

Comparison 1 Nutrient‐enriched formula versus standard term formula, Outcome 6 Bone mineralisation.

Comparison 2 "Post‐discharge" nutrient‐enriched formula versus standard term formula, Outcome 1 Growth parameters at 12‐18 months post ‐term.
Figures and Tables -
Analysis 2.1

Comparison 2 "Post‐discharge" nutrient‐enriched formula versus standard term formula, Outcome 1 Growth parameters at 12‐18 months post ‐term.

Comparison 2 "Post‐discharge" nutrient‐enriched formula versus standard term formula, Outcome 2 Development.
Figures and Tables -
Analysis 2.2

Comparison 2 "Post‐discharge" nutrient‐enriched formula versus standard term formula, Outcome 2 Development.

Comparison 3 "Preterm" nutrient‐enriched formula versus standard term formula, Outcome 1 Growth parameters at 12‐18 months post ‐term.
Figures and Tables -
Analysis 3.1

Comparison 3 "Preterm" nutrient‐enriched formula versus standard term formula, Outcome 1 Growth parameters at 12‐18 months post ‐term.

Comparison 3 "Preterm" nutrient‐enriched formula versus standard term formula, Outcome 2 Development.
Figures and Tables -
Analysis 3.2

Comparison 3 "Preterm" nutrient‐enriched formula versus standard term formula, Outcome 2 Development.

Comparison 1. Nutrient‐enriched formula versus standard term formula

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Growth rates during trial period Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 Weight gain (grams/kilogram/day)

1

33

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐1.37, 1.37]

1.2 Linear growth (millimetres/week)

1

33

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐1.07, 1.07]

1.3 Head circumference (millimetres/week)

1

33

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐0.68, 0.68]

2 Growth parameters at 6 months post ‐term Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Weight at 6 months post‐term (grams)

2

87

Mean Difference (IV, Fixed, 95% CI)

‐601.07 [‐1027.98, ‐174.15]

2.2 Crown‐heel length at 6 months post‐term (millimetres)

2

87

Mean Difference (IV, Fixed, 95% CI)

‐18.79 [‐30.00, ‐7.58]

2.3 Head circumference at 6 months post‐term (millimetres)

2

87

Mean Difference (IV, Fixed, 95% CI)

‐10.20 [‐18.02, ‐2.38]

3 Growth parameters at 9 months post ‐term Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 Weight at 9 months post term (grams)

2

296

Mean Difference (IV, Fixed, 95% CI)

152.54 [‐90.42, 395.49]

3.2 Crown‐heel length at 9 months post‐term (millimetres)

2

296

Mean Difference (IV, Fixed, 95% CI)

5.08 [‐1.58, 11.74]

3.3 Head circumference at 9 months post‐term (millimetres)

2

296

Mean Difference (IV, Fixed, 95% CI)

‐1.88 [‐5.67, 1.90]

4 Growth parameters at 12‐18 months post ‐term Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 Weight at 12‐18 months post term (grams)

3

362

Mean Difference (IV, Fixed, 95% CI)

73.51 [‐182.31, 329.32]

4.2 Crown‐heel length at 12‐18 months post‐term (millimetres)

3

362

Mean Difference (IV, Fixed, 95% CI)

4.94 [‐1.37, 11.24]

4.3 Head circumference at 12‐18 months post‐term (millimetres)

3

362

Mean Difference (IV, Fixed, 95% CI)

‐1.23 [‐4.88, 2.41]

5 Development Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

5.1 Bayley Scales of Infant Development II: Mental Development Index

2

299

Mean Difference (IV, Fixed, 95% CI)

0.23 [‐2.99, 3.45]

5.2 Bayley Scales of Infant Development II: Psychomotor Development Index

2

299

Mean Difference (IV, Fixed, 95% CI)

0.55 [‐1.95, 3.05]

6 Bone mineralisation Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

6.1 Bone area at 2 months post‐term (centimetres squared)

1

33

Mean Difference (IV, Fixed, 95% CI)

7.0 [‐15.46, 29.46]

6.2 Bone mineral content at 2 months post‐term (grams)

1

33

Mean Difference (IV, Fixed, 95% CI)

3.20 [‐4.73, 11.13]

6.3 Bone "speed of sound" assessed with ultrasound at 6 months post‐term (millimetres/second)

1

20

Mean Difference (IV, Fixed, 95% CI)

45.0 [‐18.48, 108.48]

6.4 Bone specific serum alkaline phosphatase at six months post‐term (units/litre)

1

20

Mean Difference (IV, Fixed, 95% CI)

‐9.0 [‐42.01, 24.01]

6.5 Bone width at 9 months post‐term (centimetres)

1

31

Mean Difference (IV, Fixed, 95% CI)

0.05 [‐0.01, 0.11]

6.6 Bone mineral content at 9 months post‐term (milligrams/centimetre)

1

31

Mean Difference (IV, Fixed, 95% CI)

20.60 [7.78, 33.42]

Figures and Tables -
Comparison 1. Nutrient‐enriched formula versus standard term formula
Comparison 2. "Post‐discharge" nutrient‐enriched formula versus standard term formula

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Growth parameters at 12‐18 months post ‐term Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 Weight at 12‐18 months post term (grams)

2

259

Mean Difference (IV, Fixed, 95% CI)

‐101.64 [‐405.48, 202.19]

1.2 Crown‐heel length at 12‐18 months post‐term (millimetres)

2

259

Mean Difference (IV, Fixed, 95% CI)

2.13 [‐5.49, 9.76]

1.3 Head circumference at 12‐18 months post‐term (millimetres)

2

259

Mean Difference (IV, Fixed, 95% CI)

‐4.55 [‐9.06, ‐0.04]

2 Development Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Bayley Scales of Infant Development II: Mental Development Index

1

196

Mean Difference (IV, Fixed, 95% CI)

0.90 [‐3.11, 4.91]

2.2 Bayley Scales of Infant Development II: Psychomotor Development Index

1

196

Mean Difference (IV, Fixed, 95% CI)

2.70 [‐1.16, 6.56]

Figures and Tables -
Comparison 2. "Post‐discharge" nutrient‐enriched formula versus standard term formula
Comparison 3. "Preterm" nutrient‐enriched formula versus standard term formula

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Growth parameters at 12‐18 months post ‐term Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 Weight at 12‐18 months post term (grams)

1

103

Mean Difference (IV, Fixed, 95% CI)

500.00 [25.87, 974.13]

1.2 Crown‐heel length at 12‐18 months post‐term (millimetres)

1

103

Mean Difference (IV, Fixed, 95% CI)

11.0 [‐0.21, 22.21]

1.3 Head circumference at 12‐18 months post‐term (millimetres)

1

103

Mean Difference (IV, Fixed, 95% CI)

5.0 [‐1.18, 11.18]

2 Development Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Bayley Scales of Infant Development II: Mental Development Index

1

103

Mean Difference (IV, Fixed, 95% CI)

‐1.0 [‐6.41, 4.41]

2.2 Bayley Scales of Infant Development II: Psychomotor Development Index

1

103

Mean Difference (IV, Fixed, 95% CI)

‐1.0 [‐4.30, 2.30]

Figures and Tables -
Comparison 3. "Preterm" nutrient‐enriched formula versus standard term formula