Antioxidants for preventing pre‐eclampsia
Information
- DOI:
- https://doi.org/10.1002/14651858.CD004227.pub3Copy DOI
- Database:
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- Cochrane Database of Systematic Reviews
- Version published:
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- 23 January 2008see what's new
- Type:
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- Intervention
- Stage:
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- Review
- Cochrane Editorial Group:
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Cochrane Pregnancy and Childbirth Group
- Copyright:
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- Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Authors
Contributions of authors
Alice Rumbold and Lelia Duley developed and wrote the protocol. Caroline Crowther and Ross Haslam commented on and revised the various drafts of the protocol during its development. Alice Rumbold and Caroline Crowther extracted the data. Alice Rumbold wrote the first draft of the review. Lelia Duley, Caroline Crowther and Ross Haslam commented on various versions of the review.
For the 2007 update, Alice Rumbold, Caroline Crowther and Lelia Duley extracted the data. Alice Rumbold wrote the first draft of the updated review. Lelia Duley, Caroline Crowther and Ross Haslam commented on various versions of the review.
Sources of support
Internal sources
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No sources of support supplied
External sources
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Discipline of Obstetrics and Gynaecology, The University of Adelaide, Australia.
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Medical Research Council, UK.
Declarations of interest
Caroline Crowther and Ross Haslam were chief investigators for the Australian Collaborative Trial of Supplements with vitamin C and vitamin E for the prevention of pre‐eclampsia (ACTS). Alice Rumbold was the PhD student involved with this trial (ACTS). Lelia Duley was a member of the steering committee for the Vitamins in Pregnancy (VIP) trial, which assessed vitamins C and E for prevention of pre‐eclampsia.
Acknowledgements
We thank Philippa Middleton for assisting with the data extraction and for her advice and comments regarding the format of the review. We thank Associate Professor Parul Christian and Dr Anwar Merchant for providing additional unpublished information about their trials.
As part of the pre‐publication editorial process, this review has been commented on by three peers (an editor and two referees who are external to the editorial team), one or more members of the Pregnancy and Childbirth Group's international panel of consumers and the Group's Statistical Adviser.
Version history
| Published | Title | Stage | Authors | Version |
| 2008 Jan 23 | Antioxidants for preventing pre‐eclampsia | Review | Alice Rumbold, Lelia Duley, Caroline A Crowther, Ross R Haslam | |
| 2005 Oct 19 | Antioxidants for preventing pre‐eclampsia | Review | Alice Rumbold, Lelia Duley, Caroline A Crowther, Ross RR Haslam | |
| 2003 Apr 22 | Antioxidants for preventing pre‐eclampsia | Protocol | R umbold Alice, D uley Lelia, C rowther Caroline, H aslam Ross, Alice Rumbold, Caroline A Crowther, Lelia Duley, Ross RR Haslam | |
Differences between protocol and review
We excluded quasi‐random studies. The previous version of this review included quasi‐random studies; we planned to exclude quasi‐random studies from future updates of the review, when sufficient data became available from large randomised controlled trials.
We added the following new outcomes: gestational hypertension, use of antihypertensives, miscarriage, extremely preterm birth (less than 27 completed weeks' gestation), Apgar score less than seven at five minutes and economic outcomes. These outcomes were added to ensure all outcomes specified in the pre‐eclampsia generic protocol are reported in this review.
