Vitamin supplementation for preventing miscarriage
Information
- DOI:
- https://doi.org/10.1002/14651858.CD004073.pub3Copy DOI
- Database:
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- Cochrane Database of Systematic Reviews
- Version published:
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- 19 January 2011see what's new
- Type:
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- Intervention
- Stage:
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- Review
- Cochrane Editorial Group:
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Cochrane Pregnancy and Childbirth Group
- Copyright:
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- Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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Authors
Contributions of authors
Alice Rumbold developed and wrote the protocol, extracted data and prepared the review. Ning Pan and Philippa Middleton extracted data and were involved in the analysis and writing of the review. Caroline Crowther commented on and revised the various drafts of the protocol and review during its development.
Sources of support
Internal sources
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Department of Obstetrics and Gynaecology, The University of Adelaide, Australia.
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The University of Adelaide Medical Endowment Fund, Australia.
Dr Rumbold is supported by the Jean B Reid Fellowship
External sources
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Department of Health and Ageing, Australia.
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Department of Nutrition for Health and Development, World Health Organization, Switzerland.
Provided funding for the preparation of this updated review.
Declarations of interest
Alice Rumbold and Caroline Crowther are investigators on the Australian Collaborative Trial of Supplements with vitamin C and vitamin E for the prevention of pre‐eclampsia (Rumbold 2006). This trial is included in this review but its eligibility for inclusion, trial quality assessments and data extraction were carried out independently by two of the review authors not involved in the original trial.
Acknowledgements
We thank Simon Gates for statistical advice regarding inclusion of cluster randomised trials, Lelia Duley for helpful comments on the format of the review and Sonja Henderson for assisting with review administration.
Version history
| Published | Title | Stage | Authors | Version |
| 2016 May 06 | Vitamin supplementation for preventing miscarriage | Review | Olukunmi O Balogun, Katharina da Silva Lopes, Erika Ota, Yo Takemoto, Alice Rumbold, Mizuki Takegata, Rintaro Mori | |
| 2011 Jan 19 | Vitamin supplementation for preventing miscarriage | Review | Alice Rumbold, Philippa Middleton, Ning Pan, Caroline A Crowther | |
| 2005 Apr 20 | Vitamin supplementation for preventing miscarriage | Review | Alice Rumbold, Philippa Middleton, Caroline A Crowther | |
| 2003 Jan 20 | Vitamin supplementation for preventing miscarriage | Protocol | Alice Rumbold, Caroline A Crowther | |
Differences between protocol and review
We now include trials where supplementation occurred in mid‐pregnancy. This was not specified in the original protocol for this review, but this was amended to be in line with other miscarriage reviews such as 'Progestogen for preventing miscarriage' (Haas 2009). We included trials where the onset of supplementation occurred both prior to and after 20 weeks' gestation, and when it could not be established whether the majority of the women started supplementation prior to 20 weeks' gestation. To overcome differences in the definition of miscarriage and stillbirth, we have used a combined outcome of total fetal loss (early or late miscarriage or stillbirth). We have still reported early or late miscarriage and stillbirth separately in addition to this combined outcome. Similarly, we specified in the original protocol that we would exclude studies reporting greater than 20% losses to follow‐up. In this review we have included studies that reported more than 20% losses to follow‐up and undertaken further analyses based on trial quality.
