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Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 1 CLD.
Figures and Tables -
Analysis 1.1

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 1 CLD.

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 2 Death.
Figures and Tables -
Analysis 1.2

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 2 Death.

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 3 CLD or death.
Figures and Tables -
Analysis 1.3

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 3 CLD or death.

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 4 Side effects of erythromycin.
Figures and Tables -
Analysis 1.4

Comparison 1 Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection, Outcome 4 Side effects of erythromycin.

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 1 CLD.
Figures and Tables -
Analysis 2.1

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 1 CLD.

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 2 Death.
Figures and Tables -
Analysis 2.2

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 2 Death.

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 3 CLD or death.
Figures and Tables -
Analysis 2.3

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 3 CLD or death.

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 4 Side effects of erythromycin.
Figures and Tables -
Analysis 2.4

Comparison 2 Erythromycin vs placebo in U. Urealyticum culture positive babies, Outcome 4 Side effects of erythromycin.

Comparison 1. Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 CLD Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

1.40 [0.72, 2.70]

1.1 Culture/PCR positive

1

9

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.18, 22.06]

1.2 Culture/PCR negative

1

66

Risk Ratio (M‐H, Fixed, 95% CI)

1.35 [0.68, 2.69]

2 Death Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.22, 1.83]

2.1 Culture/PCR positive

1

9

Risk Ratio (M‐H, Fixed, 95% CI)

0.58 [0.03, 11.21]

2.2 Culture/PCR negative

1

66

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.21, 2.00]

3 CLD or death Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

1.06 [0.66, 1.69]

3.1 Culture/PCR positive

1

9

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.14, 7.10]

3.2 Culture/PCR negative

1

66

Risk Ratio (M‐H, Fixed, 95% CI)

1.06 [0.66, 1.72]

4 Side effects of erythromycin Show forest plot

1

75

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 1. Prophylactic erythromycin vs placebo in babies at risk for U. Urealyticum colonization or infection
Comparison 2. Erythromycin vs placebo in U. Urealyticum culture positive babies

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 CLD Show forest plot

1

28

Risk Ratio (M‐H, Fixed, 95% CI)

0.9 [0.54, 1.50]

2 Death Show forest plot

1

28

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 CLD or death Show forest plot

1

28

Risk Ratio (M‐H, Fixed, 95% CI)

0.9 [0.54, 1.50]

4 Side effects of erythromycin Show forest plot

1

28

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 2. Erythromycin vs placebo in U. Urealyticum culture positive babies