Scolaris Content Display Scolaris Content Display

Comparison 1 Bismuth subsalicylate versus placebo, Outcome 1 Clinical improvement.
Figures and Tables -
Analysis 1.1

Comparison 1 Bismuth subsalicylate versus placebo, Outcome 1 Clinical improvement.

Comparison 1 Bismuth subsalicylate versus placebo, Outcome 2 Histological improvement.
Figures and Tables -
Analysis 1.2

Comparison 1 Bismuth subsalicylate versus placebo, Outcome 2 Histological improvement.

Comparison 2 Budesonide versus placebo, Outcome 1 Clinical improvement.
Figures and Tables -
Analysis 2.1

Comparison 2 Budesonide versus placebo, Outcome 1 Clinical improvement.

Comparison 2 Budesonide versus placebo, Outcome 2 Histological improvement.
Figures and Tables -
Analysis 2.2

Comparison 2 Budesonide versus placebo, Outcome 2 Histological improvement.

Comparison 3 Prednisolone versus placebo, Outcome 1 Clinical improvement.
Figures and Tables -
Analysis 3.1

Comparison 3 Prednisolone versus placebo, Outcome 1 Clinical improvement.

Comparison 4 Boswellia serrata extract versus placebo, Outcome 1 Clinical improvement.
Figures and Tables -
Analysis 4.1

Comparison 4 Boswellia serrata extract versus placebo, Outcome 1 Clinical improvement.

Table 1. Unblinded studies of therapies for collagenous colitis

Therapy

References

5‐ASA compounds

Weidner 1984, Farah 1985, Giardiello 1987, Wang 1987, Jessurun 1987, Eckstein 1988, Mason 1988, Rokkas 1988, O'Mahony 1990, Gubbins 1991, Giardiello 1991, Carpenter 1992, Fasoli 1994, Katanuma 1995, Bohr 1996, Goff 1997, Mullhaupt 1998, Wang 1999, Bonner 2000, Fielder 2001, Pardi 2001, Kimble 2001, Bozdech 2001, Abdo 2002, Fernandez 2003, Honkoop 2003, Randall 2003, Buchman 2004, Mowat 2005

Antibiotics

Mogensen 1984, Wang 1987, Puri 1994, Pimental 1995, Bohr 1996, Mullhaupt 1998, Swensson 1999, Pardi 2001(2), Honkoop 2001

Azathioprine/6‐mercaptopurine

Goff 1997, Pardi 2001, Pardi 2001(2)

Bismuth subsalicylate

Girard 1987, Fine 1998, Bohr 1999, Pardi 2001(2), Bozdech 2001, Buchman 2004

Budesonide

Van Gossum 1998, Delarive 1998, Lanyi 1999, Tromm 1999, Bohr 1999, Mueller‐Wittlic 2000, Bajor 2003, Fernandez 2003, Honkoop 2003, Buchman 2004, Hawkins 2004

Cholestyramine/colestipol

Andersen 1993, Bohr 1996, Ung 2000, Pardi 2001(2), Fernandez 2003, Baert 2004, Mahmoud 2005

Cyclosporine

Eijsbouts 1995, Pardi 2001(2)

Elemental diet

Teahon 1994

Ketotifen

Marshall 1998

Methotrexate

Bhullar 1996, Pardi 2001(2), Hillman 2001

Octreotide

Fisher 1996, Goff 1997, Pardi 2001(2)

Pentoxifylline

Peterson 1996, Williams 1998

Probiotics

Tromm 2004

Steroids, intravenous

Pardi 2001, Buchman 2004

Steroids, oral

Palmer 1986, Hamilton 1986, Giardiello 1987, Wang 1987, Jessurun 1987, O'Mahony 1990, Sloth 1991, Giardiello 1991, Carpenter 1992, Fasoli 1994, Pimental 1995, Katanuma 1995, Bohr 1996, Goff 1997, Duncan 1997, Wang 1999, Castellano 1999, Swensson 1999, Bonner 2000, Fielder 2001, Persoz 2001, Pardi 2001(2), Honkoop 2001, Abdo 2002, Fernandez 2003, Honkoop 2003, Buchman 2004, Mowat 2005

Steroids, topical

Wang 1987, Mason 1988, Pardi 2001(2)

Surgery

Jarnerot 1995, Alikhan 1997, Pardi 2001(2)

Symptomatic therapy: antidiarrheal agents, bulking agents, spasmolytics

Bamford 1982, Eaves 1983, Giardiello 1987, Wang 1987, Gubbins 1991, Pimental 1995, Katanuma 1995, Bohr 1996, Goff 1997, Mullhaupt 1998, Wang 1999, Fielder 2001, Pardi 2001(2), Abdo 2002, Honkoop 2003, Mowat 2005

Verapamil

Scheidler 2001

Figures and Tables -
Table 1. Unblinded studies of therapies for collagenous colitis
Comparison 1. Bismuth subsalicylate versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical improvement Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Histological improvement Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figures and Tables -
Comparison 1. Bismuth subsalicylate versus placebo
Comparison 2. Budesonide versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical improvement Show forest plot

3

94

Peto Odds Ratio (Peto, Fixed, 95% CI)

12.32 [5.53, 27.46]

2 Histological improvement Show forest plot

3

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figures and Tables -
Comparison 2. Budesonide versus placebo
Comparison 3. Prednisolone versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical improvement Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figures and Tables -
Comparison 3. Prednisolone versus placebo
Comparison 4. Boswellia serrata extract versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical improvement Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figures and Tables -
Comparison 4. Boswellia serrata extract versus placebo