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QUOROM statement
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Figure 1

QUOROM statement

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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
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Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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Forest plot of comparison: 1 ALE vs placebo, outcome: 1.1 Total cholesterol reduction (mmol/L).
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Figure 3

Forest plot of comparison: 1 ALE vs placebo, outcome: 1.1 Total cholesterol reduction (mmol/L).

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Forest plot of comparison: 1 ALE vs placebo, outcome: 1.2 LDL‐cholesterol reduction (mmol/L).
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Figure 4

Forest plot of comparison: 1 ALE vs placebo, outcome: 1.2 LDL‐cholesterol reduction (mmol/L).

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Forest plot of comparison: 1 ALE vs placebo, outcome: 1.3 HDL‐cholesterol reduction (mmol/L).
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Figure 5

Forest plot of comparison: 1 ALE vs placebo, outcome: 1.3 HDL‐cholesterol reduction (mmol/L).

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Forest plot of comparison: 1 ALE vs placebo, outcome: 1.4 Triglycerides reduction (mmol/L).
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Figure 6

Forest plot of comparison: 1 ALE vs placebo, outcome: 1.4 Triglycerides reduction (mmol/L).

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Comparison 1 Artichoke leaf extract vs placebo, Outcome 1 Total cholesterol reduction (mmol/L).
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Analysis 1.1

Comparison 1 Artichoke leaf extract vs placebo, Outcome 1 Total cholesterol reduction (mmol/L).

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Comparison 1 Artichoke leaf extract vs placebo, Outcome 2 LDL‐cholesterol reduction (mmol/L).
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Analysis 1.2

Comparison 1 Artichoke leaf extract vs placebo, Outcome 2 LDL‐cholesterol reduction (mmol/L).

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Comparison 1 Artichoke leaf extract vs placebo, Outcome 3 HDL‐cholesterol reduction (mmol/L).
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Analysis 1.3

Comparison 1 Artichoke leaf extract vs placebo, Outcome 3 HDL‐cholesterol reduction (mmol/L).

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Comparison 1 Artichoke leaf extract vs placebo, Outcome 4 Triglycerides reduction (mmol/L).
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Analysis 1.4

Comparison 1 Artichoke leaf extract vs placebo, Outcome 4 Triglycerides reduction (mmol/L).

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Comparison 1. Artichoke leaf extract vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total cholesterol reduction (mmol/L) Show forest plot

2

211

Mean Difference (IV, Fixed, 95% CI)

0.60 [0.40, 0.79]

2 LDL‐cholesterol reduction (mmol/L) Show forest plot

2

211

Mean Difference (IV, Fixed, 95% CI)

0.56 [0.34, 0.78]

3 HDL‐cholesterol reduction (mmol/L) Show forest plot

2

211

Mean Difference (IV, Fixed, 95% CI)

0.03 [‐0.11, 0.17]

4 Triglycerides reduction (mmol/L) Show forest plot

2

211

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.25, 0.22]
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Comparison 1. Artichoke leaf extract vs placebo
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