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Cochrane Database of Systematic Reviews

Drugs for nocturnal enuresis in children (other than desmopressin and tricyclics)

Information

DOI:
https://doi.org/10.1002/14651858.CD002238.pub2Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 12 December 2012see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:

  1. Cochrane Incontinence Group

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Aniruddh V Deshpande

    Department of Surgery and Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia

  • Patrina HY Caldwell

    Correspondence to: Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia

    [email protected]

  • Premala Sureshkumar

    Centre for Kidney Research, Royal Alexandra Hospital for Children, Parramatta, Australia

Contributions of authors

The review authors (AD and PC) independently assessed the studies identified by the updated searches and extracted data from the included studies. AD and PS also reviewed the included studies from the previous review and updated the risk of bias tables. AD and PC analysed the data and wrote the updated review.

Declarations of interest

None declared

Acknowledgements

This review was based on an updated review by Cathryn Glazener from the University of Aberdeen, Jonathan Evans from Nottingham University Hospitals NHS Trust and Rachel E Peto from the University of York, UK. Their review was based on one originally written by the NHS Centre for Reviews and Dissemination, University of York, UK. The original authors were Deborah Lister‐Sharp, Susan O'Meara, Matthew Bradley and Trevor A Sheldon. It is published as: A Systematic Review of the Effectiveness of Interventions for Managing Childhood Nocturnal Enuresis, CRD Report 11, NHS Centre for Reviews and Dissemination, University of York (Lister‐Sharp 1997). The York reviewers obtained information from a variety of sources, including organisations, manufacturers and individuals. These are listed in the NHS Centre for Reviews and Dissemination Report (Lister‐Sharp 1997), and we acknowledge their contribution to this review.

We would like to thank Professor Cathryn Glazener, Sheila Wallace, June Cody and Dr Muhammad Imran Omar from the Cochrane Incontinence Review Group, Aberdeen UK, for their tireless help and advice in conducting this update.

Version history

Published

Title

Stage

Authors

Version

2012 Dec 12

Drugs for nocturnal enuresis in children (other than desmopressin and tricyclics)

Review

Aniruddh V Deshpande, Patrina HY Caldwell, Premala Sureshkumar

https://doi.org/10.1002/14651858.CD002238.pub2

2003 Oct 20

Drugs for nocturnal enuresis in children (other than desmopressin and tricyclics)

Review

Cathryn MA Glazener, Jonathan HC Evans, Rachel E Peto

https://doi.org/10.1002/14651858.CD002238

Differences between protocol and review

The protocol included trials which investigated drugs other than desmopressin and tricyclics for nocturnal enuresis in children. A large variety of drugs have been studied across many pharmacological groups.The authors have deviated from the protocol on the issue of dealing with trials which include children with daytime wetting or other lower urinary tract symptoms. Following the guidelines drafted by the ICCS, we have now treated nocturnal enuresis with daytime symptoms as non‐monosymptomatic enuresis and have hence included these trials in the review as long as they focused on outcomes relevant to this review. A subgroup analysis investigating the efficacy of combination therapy with anticholinergics compared to monotherapy was undertaken (Comparison 5).