Scolaris Content Display Scolaris Content Display

Comparison 1 Live birth rate, Outcome 1 Live birth per couple.
Figures and Tables -
Analysis 1.1

Comparison 1 Live birth rate, Outcome 1 Live birth per couple.

Comparison 1 Live birth rate, Outcome 2 Live birth per couple: grouped by number of embryos transfer.
Figures and Tables -
Analysis 1.2

Comparison 1 Live birth rate, Outcome 2 Live birth per couple: grouped by number of embryos transfer.

Comparison 1 Live birth rate, Outcome 3 Live birth rate per couple: group by prognosis.
Figures and Tables -
Analysis 1.3

Comparison 1 Live birth rate, Outcome 3 Live birth rate per couple: group by prognosis.

Comparison 1 Live birth rate, Outcome 4 Live birth rate: grouped by day of randomisation.
Figures and Tables -
Analysis 1.4

Comparison 1 Live birth rate, Outcome 4 Live birth rate: grouped by day of randomisation.

Comparison 1 Live birth rate, Outcome 5 Live birth per OPU.
Figures and Tables -
Analysis 1.5

Comparison 1 Live birth rate, Outcome 5 Live birth per OPU.

Comparison 1 Live birth rate, Outcome 6 Live birth per OPU: grouped by numbers of embryos transferred.
Figures and Tables -
Analysis 1.6

Comparison 1 Live birth rate, Outcome 6 Live birth per OPU: grouped by numbers of embryos transferred.

Comparison 1 Live birth rate, Outcome 7 Live birth rate per OPU: grouped by prognosis.
Figures and Tables -
Analysis 1.7

Comparison 1 Live birth rate, Outcome 7 Live birth rate per OPU: grouped by prognosis.

Comparison 1 Live birth rate, Outcome 8 Live birth rate per ET.
Figures and Tables -
Analysis 1.8

Comparison 1 Live birth rate, Outcome 8 Live birth rate per ET.

Comparison 1 Live birth rate, Outcome 9 Live birth per ET: grouped by number of embryos transferred.
Figures and Tables -
Analysis 1.9

Comparison 1 Live birth rate, Outcome 9 Live birth per ET: grouped by number of embryos transferred.

Comparison 1 Live birth rate, Outcome 10 Live birth per ET: grouped by prognosis.
Figures and Tables -
Analysis 1.10

Comparison 1 Live birth rate, Outcome 10 Live birth per ET: grouped by prognosis.

Comparison 2 Clinical pregnancy rate, Outcome 1 Clinical pregnancy rate per couple.
Figures and Tables -
Analysis 2.1

Comparison 2 Clinical pregnancy rate, Outcome 1 Clinical pregnancy rate per couple.

Comparison 2 Clinical pregnancy rate, Outcome 2 Clinical pregnancy rate per couple: grouped by number of embryos transferred.
Figures and Tables -
Analysis 2.2

Comparison 2 Clinical pregnancy rate, Outcome 2 Clinical pregnancy rate per couple: grouped by number of embryos transferred.

Comparison 2 Clinical pregnancy rate, Outcome 3 Clinical pregnancy rate per couple: grouped by prognosis.
Figures and Tables -
Analysis 2.3

Comparison 2 Clinical pregnancy rate, Outcome 3 Clinical pregnancy rate per couple: grouped by prognosis.

Comparison 2 Clinical pregnancy rate, Outcome 4 Clinical pregnancy rate per couple: grouped by day of randomisation.
Figures and Tables -
Analysis 2.4

Comparison 2 Clinical pregnancy rate, Outcome 4 Clinical pregnancy rate per couple: grouped by day of randomisation.

Comparison 2 Clinical pregnancy rate, Outcome 5 Clinical pregnancy rate per OPU.
Figures and Tables -
Analysis 2.5

Comparison 2 Clinical pregnancy rate, Outcome 5 Clinical pregnancy rate per OPU.

Comparison 2 Clinical pregnancy rate, Outcome 6 Clinical pregnancy rate per OPU: grouped by number of embryos transferred.
Figures and Tables -
Analysis 2.6

Comparison 2 Clinical pregnancy rate, Outcome 6 Clinical pregnancy rate per OPU: grouped by number of embryos transferred.

Comparison 2 Clinical pregnancy rate, Outcome 7 Clinical pregnancy rate per OPU: grouped by prognosis.
Figures and Tables -
Analysis 2.7

Comparison 2 Clinical pregnancy rate, Outcome 7 Clinical pregnancy rate per OPU: grouped by prognosis.

Comparison 2 Clinical pregnancy rate, Outcome 8 Clinical pregnancy rate per ET.
Figures and Tables -
Analysis 2.8

Comparison 2 Clinical pregnancy rate, Outcome 8 Clinical pregnancy rate per ET.

Comparison 2 Clinical pregnancy rate, Outcome 10 Clinical pregnancy rate per ET: grouped by prognosis.
Figures and Tables -
Analysis 2.10

Comparison 2 Clinical pregnancy rate, Outcome 10 Clinical pregnancy rate per ET: grouped by prognosis.

Comparison 2 Clinical pregnancy rate, Outcome 11 Clinical pregnancy rate per ET: grouped by number of embryos transferred.
Figures and Tables -
Analysis 2.11

Comparison 2 Clinical pregnancy rate, Outcome 11 Clinical pregnancy rate per ET: grouped by number of embryos transferred.

Comparison 3 Multiple‐pregnancy rate, Outcome 1 Multiple‐pregnancy rate per couple.
Figures and Tables -
Analysis 3.1

Comparison 3 Multiple‐pregnancy rate, Outcome 1 Multiple‐pregnancy rate per couple.

Comparison 3 Multiple‐pregnancy rate, Outcome 2 Multiple‐pregnancy rate per couple: grouped by number of embryo transfer.
Figures and Tables -
Analysis 3.2

Comparison 3 Multiple‐pregnancy rate, Outcome 2 Multiple‐pregnancy rate per couple: grouped by number of embryo transfer.

Comparison 3 Multiple‐pregnancy rate, Outcome 3 Multiple‐pregnancy rate per couple: grouped by prognosis.
Figures and Tables -
Analysis 3.3

Comparison 3 Multiple‐pregnancy rate, Outcome 3 Multiple‐pregnancy rate per couple: grouped by prognosis.

Comparison 3 Multiple‐pregnancy rate, Outcome 4 High order pregnancies (more than 2 gestational sacs) per couple.
Figures and Tables -
Analysis 3.4

Comparison 3 Multiple‐pregnancy rate, Outcome 4 High order pregnancies (more than 2 gestational sacs) per couple.

Comparison 3 Multiple‐pregnancy rate, Outcome 5 High order pregnancy: grouped by number of embryos transferred.
Figures and Tables -
Analysis 3.5

Comparison 3 Multiple‐pregnancy rate, Outcome 5 High order pregnancy: grouped by number of embryos transferred.

Comparison 3 Multiple‐pregnancy rate, Outcome 6 High order pregnancies: grouped by prognosis.
Figures and Tables -
Analysis 3.6

Comparison 3 Multiple‐pregnancy rate, Outcome 6 High order pregnancies: grouped by prognosis.

Comparison 3 Multiple‐pregnancy rate, Outcome 7 Multiple‐pregnancy rate per pregnancy.
Figures and Tables -
Analysis 3.7

Comparison 3 Multiple‐pregnancy rate, Outcome 7 Multiple‐pregnancy rate per pregnancy.

Comparison 3 Multiple‐pregnancy rate, Outcome 8 High order pregnancies per total pregnancies.
Figures and Tables -
Analysis 3.8

Comparison 3 Multiple‐pregnancy rate, Outcome 8 High order pregnancies per total pregnancies.

Comparison 3 Multiple‐pregnancy rate, Outcome 9 Multiple‐pregnancy rate per pregnancy: grouped by number of embryos transferred.
Figures and Tables -
Analysis 3.9

Comparison 3 Multiple‐pregnancy rate, Outcome 9 Multiple‐pregnancy rate per pregnancy: grouped by number of embryos transferred.

Comparison 4 Miscarriage rate, Outcome 1 Miscarriage rate per couple.
Figures and Tables -
Analysis 4.1

Comparison 4 Miscarriage rate, Outcome 1 Miscarriage rate per couple.

Comparison 4 Miscarriage rate, Outcome 2 Miscarriage rate per pregnancy.
Figures and Tables -
Analysis 4.2

Comparison 4 Miscarriage rate, Outcome 2 Miscarriage rate per pregnancy.

Comparison 5 Embryo freezing rate, Outcome 1 Embryo freezing per couple.
Figures and Tables -
Analysis 5.1

Comparison 5 Embryo freezing rate, Outcome 1 Embryo freezing per couple.

Comparison 5 Embryo freezing rate, Outcome 2 Embyro freezing per couple: grouped by number of embryos transferred.
Figures and Tables -
Analysis 5.2

Comparison 5 Embryo freezing rate, Outcome 2 Embyro freezing per couple: grouped by number of embryos transferred.

Comparison 5 Embryo freezing rate, Outcome 3 Embryo freezing per couple: grouped by prognostic factors.
Figures and Tables -
Analysis 5.3

Comparison 5 Embryo freezing rate, Outcome 3 Embryo freezing per couple: grouped by prognostic factors.

Comparison 6 Failure to transfer embryos rate per couple, Outcome 1 Failure to transfer any embryos per couple.
Figures and Tables -
Analysis 6.1

Comparison 6 Failure to transfer embryos rate per couple, Outcome 1 Failure to transfer any embryos per couple.

Comparison 6 Failure to transfer embryos rate per couple, Outcome 2 Failure to transfer any embryos per couple: grouped by number of embryos transferred.
Figures and Tables -
Analysis 6.2

Comparison 6 Failure to transfer embryos rate per couple, Outcome 2 Failure to transfer any embryos per couple: grouped by number of embryos transferred.

Comparison 6 Failure to transfer embryos rate per couple, Outcome 3 Failure to transfer any embryos per couple: grouped by prognostic factors.
Figures and Tables -
Analysis 6.3

Comparison 6 Failure to transfer embryos rate per couple, Outcome 3 Failure to transfer any embryos per couple: grouped by prognostic factors.

Comparison 7 Cumulative pregnancy rate, Outcome 1 Cumulative pregnancy rate from fresh and frozen transfers.
Figures and Tables -
Analysis 7.1

Comparison 7 Cumulative pregnancy rate, Outcome 1 Cumulative pregnancy rate from fresh and frozen transfers.

Table 1. Culture Techniques of Included Studies

Trial

Culture Tech Day 2/3

Culture Tech Day 5/6

Bungum 2003

Sequential G1 VItrolife

Sequential G1/G2 Vitrolife

Coskun 2000

Sequential Medicult

Sequential G1/G2 Vitrolife

Devreker 2000

NS

NS

Emiliani 2003

In‐house sequential (based on G1/G2)

In‐house sequential (based on G1/G2)

Frattarelli 2003

Sequential NS

Sequential NS

Gardner 1998a

Single Hams F10 In‐house

Sequential G1/G2 In‐house

Hreinsson 2004

Vitro life IVF

Squential G1/G2 or CCM Vitrolife

Karaki 2002

Medicult

Sequential G1/G2 Vitrolife

Kolibianakis 2004

Sequential G1 Vitrolife

Sequential G1/G2 Vitrolife

Levitas 2004

NS

Sequential ‐ G1/G2 Vitrolife

Levron 2002

NS

NS

Livingstone 2002

Sequential ‐ Sydney IVF Cook

Sequential ‐ Sydney IVF Cook

Motta 1998

Sequential ‐ Irvines P1

Sequential ‐ Irvines P1 then Blast media

Rienzi 2002

Sequential G1 Vitrolife

Sequential G1/G2 Vitrolife

Schillaci 2002

NS

NS

Van der Auwera 2002

Sequential both Cook and Vitrolife

Sequential both Cook and Vitrolife

Figures and Tables -
Table 1. Culture Techniques of Included Studies
Table 2. Study Quality

Study ID

Grade for concealment of allocation

Method of concealment of allocation

Randomisation procedure

ITT

Similar number of embryos transferred

Prognostic factors of patients/cycles

Day of randomisation

Notes

Bungum 2003

A

Sealed envelope

Unknown

Yes, no dropouts or exclusions

Yes

Good

Day 3 post ovum pick up

Coskun 2000

A

Sealed envelope

Unknown

Yes, no dropouts or exclusions

Yes

Good

Day of ovum pick up

Devreker 2000

B

Unknown

Unknown

Yes, no dropouts or exclusions

No

Poor

Not stated

Emiliani 2003

B

Unknown

Randomisation list

10 women were subsequently excluded for protocol violations

Yes

Unselected

Start of cycle

Frattarelli 2003

A

Yes but not clear how this was achieved

Computer generated

Yes, 8 women withdrawn for when embryos did not meet criteria were added to the denominator and analysed

No

Good

Day of ovum pick up (Day 1)

Gardner 1998a

B

Unknown

Computer generated

Yes, no dropouts or exclusions

No

Good

8 days prior to ovum pick up but final decision about inclusion on day of trigger

Hreinsson 2004

B

Sealed envelope

Unknown

Yes no drop outs or exclusions

Yes

Good ‐ no poor

1 day prior to HCG

Karaki 2002

A

Sealed envelope

Unknown

Yes, no dropouts or exclusions

No

Unselected

Day 1 fertilisation

Kolibianakis 2004

C

None

Computer generated

Yes, no dropouts or exclusions

Yes

Unselected

Prior to stimulation

Levitas 2004

A

Sealed envelope

Computer generated

Yes, no dropouts or exclusions

No

Poor

Prior to stimulation

Levron 2002

A

Sealed envelope

Unknown

Yes, no dropouts or exclusions

No

Good

Day of ovum pick up (Day 1)

Livingstone 2002

A

Sealed envelope

Computer generated

20 women excluded post randomization as they did not have a transfer, not sure which group

No

Good

Prior to ovum pick up

Motta 1998 A&B

B

Unknown

Unknown

Yes, no dropouts or exclusions

No

Unselected

Not stated

Rienzi 2002

B

Unknown

Computer generated

Yes, no dropouts or exclusions

Yes

Good

Day of ovum pick up (Day 1)

Schillaci 2002

B

Unknown

Unknown

Yes, no dropouts or exclusions

No

Unselected

Day 1 fertilisation check

Van der Auwera 2002

A

Sealed envelope

Unknown

Yes, 7 dropouts after randomisation (3 from day 2, 4 from Day 5) were added to the denominator and analysed.

Yes

Unselected

Start of cycle

Figures and Tables -
Table 2. Study Quality
Comparison 1. Live birth rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Live birth per couple Show forest plot

7

629

Odds Ratio (M‐H, Fixed, 95% CI)

1.03 [0.74, 1.44]

2 Live birth per couple: grouped by number of embryos transfer Show forest plot

7

629

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.03 [0.74, 1.44]

2.1 Equal number of embryos transferred

3

405

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.00 [0.67, 1.49]

2.2 More cleavage stage than blastocyst embyros transferred

4

224

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.11 [0.60, 2.07]

3 Live birth rate per couple: group by prognosis Show forest plot

7

629

Odds Ratio (M‐H, Fixed, 95% CI)

1.03 [0.74, 1.44]

3.1 Good prognostic factors

3

245

Odds Ratio (M‐H, Fixed, 95% CI)

0.94 [0.56, 1.57]

3.2 Poor prognostic factors

2

77

Odds Ratio (M‐H, Fixed, 95% CI)

2.05 [0.53, 7.96]

3.3 Unselected group

2

307

Odds Ratio (M‐H, Fixed, 95% CI)

1.02 [0.64, 1.63]

4 Live birth rate: grouped by day of randomisation Show forest plot

7

629

Odds Ratio (M‐H, Fixed, 95% CI)

1.03 [0.74, 1.44]

4.1 Randomisation at start of cycle

3

361

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.67, 1.64]

4.2 Randomised on day of OPU and day 1 after OPU

3

245

Odds Ratio (M‐H, Fixed, 95% CI)

0.94 [0.56, 1.57]

4.3 Randomised Day 2 to 3 post OPU

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.4 Day of randomisation unstated

1

23

Odds Ratio (M‐H, Fixed, 95% CI)

4.13 [0.36, 47.30]

5 Live birth per OPU Show forest plot

6

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Live birth per OPU: grouped by numbers of embryos transferred Show forest plot

7

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6.1 Equal number of embryos transferred

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 More cleavage stage than blastocyst embryos transferred

5

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Live birth rate per OPU: grouped by prognosis Show forest plot

6

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7.1 Good prognosis

3

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.2 Poor prognosis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.3 Unselected

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Live birth rate per ET Show forest plot

8

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9 Live birth per ET: grouped by number of embryos transferred Show forest plot

8

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9.1 Equal number of embryos transferred

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.2 More cleavage stage than blastocyst embryos transferred

6

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Live birth per ET: grouped by prognosis Show forest plot

8

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

10.1 Good prognosis

4

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10.2 Poor prognosis

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10.3 Unselected

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 1. Live birth rate
Comparison 2. Clinical pregnancy rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Clinical pregnancy rate per couple Show forest plot

15

2042

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.88, 1.26]

2 Clinical pregnancy rate per couple: grouped by number of embryos transferred Show forest plot

15

2042

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.88, 1.26]

2.1 equal numbers of ET

6

1157

Odds Ratio (M‐H, Fixed, 95% CI)

1.06 [0.83, 1.34]

2.2 more cleavage stage than blastocyst embryos transfered

9

885

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.80, 1.38]

3 Clinical pregnancy rate per couple: grouped by prognosis Show forest plot

15

2042

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.88, 1.26]

3.1 Good prognostic factors

7

800

Odds Ratio (M‐H, Fixed, 95% CI)

0.94 [0.71, 1.25]

3.2 Poor prognostic factors

2

77

Odds Ratio (M‐H, Fixed, 95% CI)

2.69 [0.81, 8.96]

3.3 Unselected group

6

1165

Odds Ratio (M‐H, Fixed, 95% CI)

1.10 [0.86, 1.39]

4 Clinical pregnancy rate per couple: grouped by day of randomisation Show forest plot

15

2042

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.88, 1.26]

4.1 Randomised start of cycle

5

913

Odds Ratio (M‐H, Fixed, 95% CI)

1.12 [0.85, 1.47]

4.2 Randomised on day of OPU or day 1

7

872

Odds Ratio (M‐H, Fixed, 95% CI)

1.04 [0.79, 1.37]

4.3 Randomised on day 2 to 3

1

118

Odds Ratio (M‐H, Fixed, 95% CI)

0.64 [0.31, 1.34]

4.4 Day of randomisation unstated

2

139

Odds Ratio (M‐H, Fixed, 95% CI)

1.23 [0.61, 2.49]

5 Clinical pregnancy rate per OPU Show forest plot

15

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Clinical pregnancy rate per OPU: grouped by number of embryos transferred Show forest plot

15

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6.1 Equal numbers of embryos transferred

6

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 More cleavage stage than blastocyst embryos transferred

9

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Clinical pregnancy rate per OPU: grouped by prognosis Show forest plot

15

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7.1 Good prognosis

7

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.2 Poor prognosis

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.3 Unselected

6

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Clinical pregnancy rate per ET Show forest plot

16

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

10 Clinical pregnancy rate per ET: grouped by prognosis Show forest plot

16

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

10.1 Good prognosis

8

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10.2 Poor prognosis

2

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10.3 Unselected

6

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Clinical pregnancy rate per ET: grouped by number of embryos transferred Show forest plot

16

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

11.1 Equal number of embryos transferred

6

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

11.2 More cleavage stage than blastocyst embryos transferred

10

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 2. Clinical pregnancy rate
Comparison 3. Multiple‐pregnancy rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Multiple‐pregnancy rate per couple Show forest plot

12

1807

Odds Ratio (M‐H, Fixed, 95% CI)

0.85 [0.63, 1.13]

2 Multiple‐pregnancy rate per couple: grouped by number of embryo transfer Show forest plot

12

1807

Odds Ratio (M‐H, Fixed, 95% CI)

0.85 [0.63, 1.13]

2.1 Equal number of embryos transferred

6

1157

Odds Ratio (M‐H, Fixed, 95% CI)

0.91 [0.63, 1.32]

2.2 More cleavage stage than blastocyst embryos transferred

6

650

Odds Ratio (M‐H, Fixed, 95% CI)

0.76 [0.48, 1.21]

3 Multiple‐pregnancy rate per couple: grouped by prognosis Show forest plot

12

1807

Odds Ratio (M‐H, Fixed, 95% CI)

0.84 [0.63, 1.12]

3.1 Good prognostic factors

7

824

Odds Ratio (M‐H, Fixed, 95% CI)

0.75 [0.50, 1.12]

3.2 Poor prognostic factors

1

54

Odds Ratio (M‐H, Fixed, 95% CI)

0.89 [0.14, 5.81]

3.3 Unselected

4

929

Odds Ratio (M‐H, Fixed, 95% CI)

0.96 [0.62, 1.47]

4 High order pregnancies (more than 2 gestational sacs) per couple Show forest plot

10

1520

Odds Ratio (M‐H, Fixed, 95% CI)

0.44 [0.15, 1.33]

5 High order pregnancy: grouped by number of embryos transferred Show forest plot

10

1520

Odds Ratio (M‐H, Fixed, 95% CI)

0.44 [0.15, 1.33]

5.1 Equal number of embryos transferred

6

1157

Odds Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.28]

5.2 More cleavage stage than blastocyst embryos transferred

4

363

Odds Ratio (M‐H, Fixed, 95% CI)

0.46 [0.14, 1.49]

6 High order pregnancies: grouped by prognosis Show forest plot

10

1520

Odds Ratio (M‐H, Fixed, 95% CI)

0.44 [0.15, 1.33]

6.1 Good prognostic factors

7

870

Odds Ratio (M‐H, Fixed, 95% CI)

0.29 [0.08, 1.06]

6.2 Poor prognostic factors

1

54

Odds Ratio (M‐H, Fixed, 95% CI)

4.2 [0.16, 107.89]

6.3 Unselected

2

596

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Multiple‐pregnancy rate per pregnancy Show forest plot

12

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

8 High order pregnancies per total pregnancies Show forest plot

11

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9 Multiple‐pregnancy rate per pregnancy: grouped by number of embryos transferred Show forest plot

11

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9.1 Equal number of embryos transferred

5

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.2 More cleavage stage than blastocyst embryos transferred

6

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 3. Multiple‐pregnancy rate
Comparison 4. Miscarriage rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Miscarriage rate per couple Show forest plot

10

1453

Odds Ratio (M‐H, Fixed, 95% CI)

1.36 [0.91, 2.02]

2 Miscarriage rate per pregnancy Show forest plot

11

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

Figures and Tables -
Comparison 4. Miscarriage rate
Comparison 5. Embryo freezing rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Embryo freezing per couple Show forest plot

9

1416

Odds Ratio (M‐H, Fixed, 95% CI)

0.45 [0.36, 0.56]

2 Embyro freezing per couple: grouped by number of embryos transferred Show forest plot

9

1416

Odds Ratio (M‐H, Fixed, 95% CI)

0.45 [0.36, 0.56]

2.1 Equal number of embryos transferred

5

956

Odds Ratio (M‐H, Fixed, 95% CI)

0.42 [0.32, 0.55]

2.2 More cleavage stage than blastocyst embryos transferred

4

460

Odds Ratio (M‐H, Fixed, 95% CI)

0.51 [0.36, 0.74]

3 Embryo freezing per couple: grouped by prognostic factors Show forest plot

9

1416

Odds Ratio (M‐H, Fixed, 95% CI)

0.45 [0.36, 0.56]

3.1 Good prognostic factors

5

542

Odds Ratio (M‐H, Fixed, 95% CI)

0.41 [0.28, 0.58]

3.2 Poor prognostic factors

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 Unselected

4

874

Odds Ratio (M‐H, Fixed, 95% CI)

0.48 [0.36, 0.62]

Figures and Tables -
Comparison 5. Embryo freezing rate
Comparison 6. Failure to transfer embryos rate per couple

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Failure to transfer any embryos per couple Show forest plot

14

1944

Odds Ratio (M‐H, Fixed, 95% CI)

3.21 [2.15, 4.81]

2 Failure to transfer any embryos per couple: grouped by number of embryos transferred Show forest plot

14

1944

Odds Ratio (M‐H, Fixed, 95% CI)

3.21 [2.15, 4.81]

2.1 Equal number of embryos transferred

6

1157

Odds Ratio (M‐H, Fixed, 95% CI)

2.67 [1.63, 4.39]

2.2 More cleavage stage than blastocyst embryos tranferred

8

787

Odds Ratio (M‐H, Fixed, 95% CI)

4.42 [2.18, 8.98]

3 Failure to transfer any embryos per couple: grouped by prognostic factors Show forest plot

14

1944

Odds Ratio (M‐H, Fixed, 95% CI)

3.21 [2.15, 4.81]

3.1 Good prognostic factors

7

800

Odds Ratio (M‐H, Fixed, 95% CI)

1.58 [0.65, 3.82]

3.2 Poor prognostic factors

2

77

Odds Ratio (M‐H, Fixed, 95% CI)

5.12 [0.93, 28.26]

3.3 Unselected

5

1067

Odds Ratio (M‐H, Fixed, 95% CI)

3.74 [2.32, 6.03]

Figures and Tables -
Comparison 6. Failure to transfer embryos rate per couple
Comparison 7. Cumulative pregnancy rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Cumulative pregnancy rate from fresh and frozen transfers Show forest plot

3

420

Odds Ratio (M‐H, Fixed, 95% CI)

0.58 [0.39, 0.87]

Figures and Tables -
Comparison 7. Cumulative pregnancy rate